Project description
Write a proposal to address the two specific hypotheses listed below.
For each set of experiments, make sure to include appropriate controls and what results you would expect if the hypothesis is supported. This assignment is based on the information content of two papers: Kearse et al., 2011, and Kearse et al., 2013.
In order to complete the assignment, it 3 other sources will be used to develop the experimental plan requested in the assignment. Include a list of all references used for the paper.
General Hypothesis: eRpL22 family paralogues (eRpL22 and eRpL22-like) retain a conserved set of ribosomal functions, yet specify unique cellular roles in fly development and in spermatogenesis.
Question 1. What experimental approach(es) would you devise to test the specific hypothesis: that specialized ribosomes exist for differential translation of testis-specific mRNAs in Drosophila?
Note that all molecular, biochemical, genetic, and cellular reagents (e.g., DNA clones, antibodies, fly strains) available from Kearse et al. (2011, 2013) are available to you for your experimental approach. If other reagents are needed for the experiments that you devise, you must include a strategy for making those necessary reagents as well as the experimental approach for using the reagents.
Question 2. What experimental approach(es) would you devise to test the specific hypothesis that testis-specific post-translational modifications including SUMOylation and phosphorylation are required to localize eRpL22 to the nucleoplasm of meiotic spermatocytes in Drosophila?
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