• To investigate the effect of rod-cone photoreceptor coupling on different stages of cone degeneration by the use of Rhodopsin knockout and rd1 mice.
Literature Review
Gap junctions are apposite to the propagation of retinal neurons and cell lines due to the introduction of cell death-inducing signals or mutagens. According to Cusato et al. (2003), carbenoxolone is a gap junction inhibitor that reduces the frequency of dying photoreceptor cells in the growing retina. It is obligatory to note that these cells die as the retina develops (Abd-El-Barr, Pennesi, Saszik, Barrow & Lem, 2009). Their hypothesis is conclusive of the fact that these cells communicate via gap junctions (Cusato et al., 2003).
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