1. Compare and contrast the histopathological changes that occur in ulcerative colitis and Crohn’s
disease.
Marking scheme
Outline inflammatory bowel disease
Requires biopsy for confirmation – histopathology – differential diagnosis:
cryptitis and crypt abscesses, transmural inflammation, granulomas, fissuring, neuromuscular
hyperplasia – CD
diffuse mucosal inflammation, crypt abscesses, crypt distortion, paneth cell metaplasia, mucosal
ulceration – UC
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