Project description
‘Multilateral Institutions, Supranational Polities and Regional Bodies’,
‘Contemporary Diplomacy, research book by Geofrey Allen Pigman
Project description
Remember that you’ll want to summarize all of the readings, along with mention of the text and authors, then suggest your narrowed focus for the response. Then you’ll use textual examples for analysis of the text and reflection on how the text relates to the course and to the project.
(introduction paragraph with a short summary of the readings and a thesis statement indicating how you’ll focus your analysis and reflection of the texts since you cannot possibly cover every point from the texts in a one page response; body paragraphs where you focus on the theme or topic you’ve decided to analyze and reflect upon; final paragraph where you reflect upon how the readings relate to the current project and the course at large).
rather than saying “author” state the author’s name.
I need one page summarizing the pdf attached
User Name: SWS213F15_15
Password: password
Host String: SQLD
I will soon upload a file named “Methods and Results New”; please write a discussion/conclusion for the paper in the section following the heading ‘Discussion’.
Please, I want you to first briefly tell me what you can tell from the results. So you’ll need to read the methods and results sections THOROUGHLY. (Note: a good response=1 log reduction by 1month, 2 log reduction by 3 months, 3 log reduction by 6 months. A complete molecular response CMR= 0 BCR-ABL signal). Discussion should include reference to the database of known ABL mutations (I’ll upload this shortly) and we need to make recommendations for future treatment regimens appropriate for each patient. Conclusion should refer to the potential of molecular methods to aid in the diagnosis, monitoring, and mutation detection for personalized medical treatment.
This is what I can tell for now:
1. end-point PCR: The most common breakpoints for BCR-ABL are B2A2 and B3A2. This has been well-documented in many research papers and review articles (please find a reference article for this; I only know this because our professor told us so), and our results support this. Of the 20 patients we analysed, all except 2 patients had either B2A2, or B3A2, or both (there were 2 patients who had both). I’m not sure what we should say about the 2 patients who did not have any of these, or the 2 patients who had both. Well, I initially thought that (1) the 2 patient could have had mutations in the primer binding sites such that the primers could no longer bind to their normal binding sites….but this would have resulted in other problems unless the mutation was a silent one. And the chance of having a mutation at the primer binding sites as well as the chromosomal aberration is low, I think. (2) or it could have been that the patient had a different rare mutation that does not involve BCR exon 13,14 or ABL exon 2,3. I think this is more likely. If you look up google for “CML breakpoints”, you should be able to see what I mean by this. (3) or it could have been just due to experimental errors: too much cDNA was lost during the procedure, or too little was loaded onto the gel that it ended up undetectable, or it was mistakenly not added. Can you think of any other experimental errors? Please tell me if you can come up with a different explanation, or which one you think is most likely.
For
2.Qualitative PCR & Gene sequencing: Patient 1 showed only a sub-optimal response to Imatinib although no mutation was found with DNA sequencing. Furthermore, the BCR-ABL/BCR ratio slightly increased in the latest month.The patient needs to be monitored regularly after this, because it is very likely that the patient will soon develop a mutation that confers resistance to Imatinib. In that case, depending on the nature of the drug, the patient will need to receive either an increased dose of Imatinib or another drug such as Dasatinib. I’ll write more in a personal msg.
Please discuss one very noble or very generous character in a fairy tale. Please write one paragraph.
What is an argument? What is a tautology?
Provide an example of modus ponens using real world statements, or premises.
What are some scenarios in which you have used arguments that meet the definition you’ve stated here?
Here is my classmates answers that you must write an answer to.
What is an argument? What is a tautology?
An argument is a sequence of statements that end with a conclusion.
A tautology is a compound proposition that is always true, regardless what the truth values of the propositional variables are.
Provide an example of modus ponens using real world statements, or premises.
“If the Royals win 4 out of 7 World Series games, then they are World Series champions.”
“The Royals won 4 out of 7 World Series games.”
——————————————————————————————————-
THEREFORE “The Royals are World Series champsions.”
What are some scenarios in which you have used arguments that meet the definition you’ve stated here?
Modus ponens can be seen frequently throughout the day all over the world as it is more or less an argument of common sense. For instance, if you buy a lottery ticket in hopes of (obviously) winning the lottery:
“If the lottery drawing draws 1 2 3 4 5 6, you win the lottery.”
“The lottery drew 1 2 3 4 5 6.”
———————————————————————–
THEREFORE “You win the lottery.”
Here is the second classmate.
An argument is a series of premises that if all true prove a conclusion. A tautology is when the combination of propositions is always true no matter what truth values the propositions have. For example, the rule of inference called modus ponens is based on the tautology that ( p^(p->q))->q. A real life example of modus ponens would be as follows:
If it is cold outside, then I will wear a coat.
It is cold outside.
Therefore,
I will wear a coat.
qed
Changing our propositions into propositional variables we will let p represent “it is cold outside” and let q represent “It is cold outside.”
Now, the argument has the form:
p->q
p
Therefore, q
qed
I use the aforementioned argument very frequently as the weather is beginning to change in my region.
Another example would be in establishing expectations for employees at work as follows:
If you master your current position, then you begin training on another position.
You master your current position.
Therefore, you begin training on another position.
qed
I can think of countless examples where this form of argumentation is used. For instance, in proof of solving an algebraic equation for x,
if x plus 12 equals 17, x equals 5
x plus 12 equals 17
Therefore, x equals 5
qed
A machining center in a local manufacturing company has five jobs to complete. The jobs are labeled 1, 2, 3, 4, and 5 based on the order they entered the shop. Your manager has asked you to compare two different job sequences to determine the best order for processing the jobs – First-In, First-Out (FIFO) and Shortest Processing Time (SPT). Compare the two sequences. Which sequence would you recommend and why? Be sure to include a variety of measures (average completion time, lateness, etc.) to compare the two sequencing rules. Include all calculations in your response.
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For this part of the final project, you will be given a scenario in which you are asked to illustrate your financial computation and analysis skills.
This part of the assessment addresses the following course outcomes: Compute financial ratios, time value, variables, and returns using industry standard tools for optimizing financial success Analyze corporate financial data for multiple companies in evaluating past and future financial performances Part II Prompt For this section of your employment exam, you will select two companies. The first company needs to come from your TDAU thinkorswim portfolio. The second needs to be a competitor of the first company from the same industry. You will be responsible for collecting, synthesizing, and making decisions regarding both companies. After evaluating these companies’ financial data, you will then decide which company’s stock is the better investment. This section of your employment examination must be submitted in two parts. Part A will contain the workbooks that house all of your quantitative data and formulas, along with any of the information that is relevant for your chosen companies. Part B will contain your answers to the questions asked below, composed in a cohesive manner. If you are referring to data that is found within the workbooks in Part A, be sure to include a citation—for example, “rate of return is 3.570 USD (E64, WB2),” where E64 is the cell that the calculation took place in and WB2 is designating “workbook 2.” This ensures that your instructor can quickly and accurately check data entry, formula use, and financial calculations. Your submission must address the following critical elements: I. Preparing the Workbooks A. Download the annual income statements, balance sheets, and cash flow statements for the last three completed fiscal years for your chosen companies. This information must be included in your final submission. B. Prepare a worksheet for each of the companies to display their financial data for the last three fiscal years. Ensure your data is accurate and organized. Include these worksheets as a workbook in your final submission. C. Find historical stock prices for both companies and add this information to the respective spreadsheets. Consider the appropriate date range you should use. II. Three-Year Returns A. What is the three-year return on the stock price of the first company (Company A)? How is the stock performing? Ensure that you use the appropriate formula in your spreadsheets to calculate the three-year return on the given company’s stock price. B. What is the three-year return on the stock price of the second company (Company B)? How is this stock performing? Ensure that you use the appropriate formula in your spreadsheets to calculate the three-year return on your chosen company’s stock price. C. How do these two stocks compare in terms of three-year returns? What does this indicate about these two companies? III. Financial Calculations A. Using the appropriate spreadsheets, which are to be included in the workbooks, calculate the price-to-earnings ratio for the last three fiscal years of the given and your chosen companies. Be sure that you are entering and using the correct formula. B. Using the appropriate spreadsheets, which are to be included in the workbooks, calculate the debt-to-equity ratios for the last three fiscal years of the given and your chosen companies. Be sure that you are entering and using the correct formula. C. Using the appropriate spreadsheets, which are to be included in the workbooks, calculate the return-on-equity ratios for the last three fiscal years of the given and your chosen companies. Be sure that you are entering and using the correct formula. D. Using the appropriate spreadsheets, which are to be included in the workbooks, calculate the earnings per share for the last three fiscal years of the given and your chosen companies. Be sure that you are entering and using the correct formula. E. Using the appropriate spreadsheets, which are to be included in the workbooks, calculate the profit margins for the last three fiscal years of the given and your chosen companies. Be sure that you are entering and using the correct formula. F. Using the appropriate spreadsheets, which are to be included in the workbooks, calculate the free cash flows for the last three fiscal years of the given and your chosen companies. Be sure that you are entering and using the correct formula. IV. Industry Averages A. Obtain past and current industry averages of three of the financial calculations above for both companies and add this information to your spreadsheet for comparison. Ensure the accuracy and organization of your data. B. In this context, how is each company’s financial health? How do these two companies compare to one another? Consider the appropriate date range you should use. V. Performance Over Time A. Analyze the performance of the Company A over time. What financial strengths and weaknesses does this company have? Consider addressing the free cash flows and ratios you calculated earlier. B. Analyze the performance of your Company B over time. What financial strengths and weaknesses does this company have? Consider addressing the free cash flows and ratios you calculated earlier. C. Analyze how the data differ between these two companies. Why do you think this is? Consider addressing the free cash flows and ratios you calculated earlier. VI. Investment A. Are the companies considered growth or value companies? Why? B. Which company’s stock is the better investment? Consider supporting your answer with data. Final Project Part II Rubric Guidelines for Submission: This part of the final project will be submitted in two parts. Part A will contain the workbooks that house all of your quantitative data and formulas, along with any of the information that is relevant for your chosen company. Part B will contain your answers to the prompts, composed in a cohesive manner. Part B should use double spacing, 12-point Times New Roman font, and one-inch margins. Citations should be formatted according to APA style. |
our Future Career: Data, Information, Hardware and Software
Section I
Describe the data and information utilized in your future career. You may visit with anyone you know that is currently working in your future career. You can also search for credible websites and don’t forget to take a look at electronic scholarly journal articles.
Briefly summarize your future career.
Summarize (describe) the data, aka “facts”, that are collected and input into a computer system.
Summarize (describe) the information, aka “output (processed data).
Reminder: information is processed data (information is data that is endowed with relevance and importance, where data are the mere facts).
Section II
Summarize the type of hardware and software you will likely use (personally) in your future career.
For example:
Laptop?
Desktop?
Smartphone?
Tablet?
Input devices?
Output devices?
What are you required to carry with you?
What are you required to have in your car?
What are you required to have at home?
Other technology?
Also include the names of common software applications used in your future career and their purpose.
Be sure to use credible sources.
Formatting (and other important directions):
A minimum of 250 words per section (titles, page numbers, your name, etc. do not count towards the minimum number of words)
Include an APA formatted reference section
Use MS Word
Use Times New Roman font, 12 pt. and 1” inch margins (top, bottom, left and right)
Use single spacing
Insert a page break between sections