Many signalling pathways in the cell are regulated by molecular switches that can be activated and inactivated under a variety of circumstances. We study in particular small GTPases. They cycle between an active GTP-bound state and an inactive GDP-bound state. In its active state the GTPases interact with a multitude of effectors that relay upstream signals to celluar components to elicit an effect, for example re-organisation of the cytoskeleton. We are currently investigating a small GTPase called RhoBTB3. RhoBTB proteins participate in regulation of vesicle transport and of the cell cycle, and they have been also described as tumour suppressors but little is known about their mechanism of action. To clarify this we are characterizing animals that do not produce RhoBTB3 and as a consequence show alterations in their skeleton. Interested students will have the opportunity to quantify these alterations in PET (positron emission tomography) scans of mice lacking RhoBTB3 and their wild type counterparts.
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