Sickle-cell disease is a genetic disorder that causes abnormal structure of hemoglobin molecule and interferes with its ability to transport oxygen. Although the sickle-cell disease is lethal if not treated, in some regions sickle-cell allele can reach frequencies as high as 15/20%. How can such a harmful allele be so common?

Assignment Question

Sickle-cell disease is a genetic disorder that causes abnormal structure of hemoglobin molecule and interferes with its ability to transport oxygen. Although the sickle-cell disease is lethal if not treated, in some regions sickle-cell allele can reach frequencies as high as 15/20%. How can such a harmful allele be so common?

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